All experiments with NOR and OLR discrimination index analyzed using a one-sample t -test comparing novel object preference to chance level of 0. Additional file 4: Figure S4. Reprints and Permissions. Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3 dioxygenase activation. Kodl, C. Metformin: Beyond Diabetes View all 12 Articles. Barbara C Fam. High-fat diet HFD mice develop object memory impairment and transient anxiety-like behaviors. Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity.
Impact of diet on learning, memory and cognition View all 11 Articles. Obesity-associated comorbidities such as cognitive impairment and anxiety are increasing public health burdens that have gained prevalence in children. To better understand the impact of childhood obesity on brain function, mice were fed with a high-fat diet HFD from weaning for 1, 3 or 6 weeks. Additionally, these mice displayed anxiety-like behavior by measure of both the open-field and elevated zero maze EZM testing. Glyburide, a second-generation sulfonylurea for the treatment of type 2 diabetes, was chosen as a countermeasure based on previous data exhibiting its potential as an anxiolytic. Interestingly, a single dose of glyburide corrected deficiencies in NOR and mitigated anxiety-like behaviors in mice fed with HFD-diet for 3-weeks. Taken together these results indicate that a HFD negatively impacts a subset of hippocampal-independent behaviors relatively rapidly, but such behaviors normalize with age.
The final manuscript was read and approved by all authors. All experiments with NOR and OLR discrimination index analyzed using a one-sample t -test comparing novel object preference to chance level of 0. In particular, the expression of IL, a key mediator of the inflammatory response in the gut, is upregulated in the ileum of the animals fed the HF diet. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Figure 1. Whilst this study revealed that diet alone is a driver of physiological changes in the ileum, it also highlighted an unexpected increase in expression of genes encoding L. J Clin Invest. Rev Bras Cineant Desemp Hum.