It has been in continuous use for almost a century for the treatment of epilepsy and has shown good tolerability, even in children. They are sometimes accompanied with significant side effects including lymphopenia, multifocal leukoencephalopathy, and malignancy. Consequently, it may be more favourable for some patients to pursue a relatively risk-free dietary approach that has the potential to reduce disease progression without affecting immune response. Cell Reports. Frontiers in Microbiology. The ketogenic diet normalized concentrations of the colonic microbiome after 6 months. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis.
I did it for 3 months in the lead up to my wedding. Here is a quick summary of my experience. I lost a bunch of weight out the gate almost 10 lbs in less than 2 weeks! My bowels seemed to like the diet for the first month and then everything went haywire. I started seeing things I used to see when I was full blown celiac like pieces of undigested food and some mucous… not cool! The same trend held for my energy and mental state. Then, I started to become anxious. I found myself becoming worse and worse at handling stress. I was much more emotional and eventually my energy tanked. After my wedding I started to reintroduce carbohydrates in a slow and measured manner and sure enough, my energy and mood stabilized, my bowels sorted themselves out and yes, I gained most of the weight back.
Gut microbiota GM is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. KD, understood in a broad sense, refers to whatever dietetic approximation, which causes physiological ketosis. Involved biological mechanisms in ketotherapeutic effects are still to be unravelled. In fact, germ-free animals were resistant to ketotherapeutic effects; reinforcing keto microbiota may be a powerful contributor to host disease recovery. In this review, we will comment the influence of gut microbiota on host, as well as, therapeutic potential of ketogenic diets and keto microbiota to restore health status. Current progress and limitations will be argued too. In spite of few studies have defined applicability and mechanisms of KD, in the light of results, keto microbiota might be a new useful therapeutic agent. Gut microbiota constitute a complex and dynamic ecosystem formed by bacteria, archaea, viruses, and fungi [ 1 ].